[28080] Тут можно
投稿者：Ремонт бесперебойников Belkin в Иркутске 投稿日：2025/09/26(Fri) 06:23
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[28079] Target’s in a brand
投稿者：Kerrykanna 投稿日：2025/09/26(Fri) 06:22
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- Target is in trouble. And while it’s easy to get lost in the company’s recent (poor) handling of American culture war narratives that cast it as too “woke” or too willing to cave to online fascists, the root of Target’s problems runs deep.
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Don’t get me wrong the massive consumer boycotts from Black organizers have done damage. And there are probably folks on the far right who think even Target’s toned-down, overwhelmingly beige Pride merch this year was still too loud.
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But its stock is in the gutter and sales have been falling for two years because of good ol’ business fundamentals. It overstocked. It lost the pulse of its customers. It went up against Amazon Prime with… actually, does anyone know what Target’s Amazon Prime competitor is called?
The brand we petite bourgeoisie once playfully referred to as Tar-zhay has lost its spark. The company reported a decline in sales for a third-straight quarter, part of a broader trend of falling or flat sales for two years. Employees have lost confidence in the company’s direction. And 2025 has been a particularly rough financially, as Black shoppers organized a boycott over Target’s decision to cave to right-wing pressure on diverse hiring goals.
Shares were down 10% Wednesday.
It’s not to say the new guy, Michael Fiddelke, is unqualified. He’s been at Target since he started as an intern more than 20 years ago, after all. But Wall Street is clearly concerned that Target’s leadership is underestimating the severity of the need for a significant change just as President Donald Trump’s tariffs on imported goods threaten the entire retail industry.
Appointing a company lifer “does not necessarily remedy the problems of entrenched groupthink and the inward-looking mindset that have plagued Target for years,” Neil Saunders, an analyst at GlobalData Retail, said in a note to clients Wednesday.
Missing the mark
In its 2010s heyday, Target became a go-to for consumers who liked a bargain but didn’t necessarily like bargain-hunting. The shelves felt well-curated. You’d go to Target because it had one thing you needed and 12 things you didn’t know you needed. It was stocked with Millennial cringe long before Gen Z gave us the term Millennial cringe.
Target’s sales held strong through the pandemic as remote workers set up home offices and stocked up on essentials. Months of lockdown also benefited the store as people began refreshing their spaces because they didn’t really have much else to do and they were staring at the same walls all the time.https://tripsca43.win
[28078] aviatorbatery.in ца
投稿者：Robertflice 投稿日：2025/09/26(Fri) 06:22
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[28077] Im glad I now registered
投稿者：Kelvin 投稿日：2025/09/26(Fri) 06:21
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[28076] Тут можно
投稿者：Ремонт планшетов iconBit в Новосибирске 投稿日：2025/09/26(Fri) 06:21
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[28075] Audifort: The Smart Choice for Hearing Support
投稿者：audifort official site 投稿日：2025/09/26(Fri) 06:21
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- Martin describes their jetpack as each "aviation" and a "recreational car." Two concepts at odds with one another? No fear -- gasoline-operated mass-market jetpack use will likely be safe and easy, according to Martin, with automated hover, stability in "reasonable weather," and a parachute. Whether somebody takes bullet point notes of your answers, you write down solutions, or you record your self, these solutions will function a basis for the subsequent steps. This will assist to ensure that the complement is secure so that you can take and is not going to work together with any other medication or condition that you may have. Ingredients similar to GABA and Gymnema Sylvestre assist soothe anxiety and enhance sleep, while antioxidants defend in opposition to free radical harm that may affect auditory cells. The average Medicare Advantage premium is projected to be $17 in 2025, while Medigap premiums could run wherever from around $65 to $450, relying on the type of Medigap plan you choose and your location. Medicare Supplement Insurance plans, also referred to as Medigap, don't present protection for hearing aids. Sonofit will not be a scam, it's a legitimate complement that can help folks with hearing problems. Here is my blog; http://114.55.58.6:3000/josephinehartw/1973audifort-reviews/wiki/The+last+Word+Solution+For+Hearing+Supplement+That+you+can+Learn+about+Today
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[28074] Тут можно
投稿者：Ремонт телефонов Neffos в Санкт-Петербурге 投稿日：2025/09/26(Fri) 06:21
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[28073] Everstake
投稿者：Everstake 投稿日：2025/09/26(Fri) 06:21
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[28072] What Are you able to Do To avoid wasting Your Dosage Anavar Homme From Destruction By Social Media?
投稿者：anavar dosage bodybuilding forum 投稿日：2025/09/26(Fri) 06:21
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- Oxandrin Oxandrolone: Side Effects, Uses, https://www.valley.md/anavar-dosage-for-men, Interactions, Warnings Below is a compact "cheat‑sheet" that pulls together most of the concepts you listed into an easy‑to‑reference framework. It’s organized in three parts: Drug classification & pharmacological action – what the drug does and why it matters. Mechanisms, targets and examples – how the drug exerts its effect (receptor, enzyme, ion channel, etc.). Drug development cycle – from discovery to post‑marketing surveillance. 1. Drug Classification & Pharmacological Action Class What it’s used for Primary pharmacodynamic property Analgesics / Anti‑inflammatories (NSAIDs, opioids) Pain relief; anti‑inflammatory COX inhibition, μ‑opioid receptor agonism, etc. Antibiotics Treat bacterial infections Cell wall synthesis inhibition, protein synthesis blockade, DNA replication interference, etc. Antivirals Treat viral infections Reverse transcriptase inhibition (HIV), protease inhibition (HCV), polymerase inhibition (influenza), entry blockers, etc. Antifungals Treat fungal infections Ergosterol synthesis inhibition, cell membrane disruption. Cytotoxic agents (chemotherapy) Treat cancer DNA alkylation, topoisomerase inhibition, microtubule destabilization, immune checkpoint blockade, etc. Immunomodulators Treat autoimmune diseases TNF-α inhibitors, IL‑6 inhibitors, JAK inhibitors, T cell co-stimulation blockers. --- 2. Chemical Classes of Active Agents Below is a list of major chemical scaffolds that have been successfully harnessed for each therapeutic purpose. Therapeutic Area Common Chemical Scaffolds / Substructures Antibiotics β‑lactam core (penams, cephalosporins), monobactam, carbapenems; glycopeptide ring system (vancomycin); oxazolidinone nucleus (linezolid); macrolide lactone ring (erythromycin). Antivirals Nucleoside analogs with sugar moiety and heteroaromatic base (e.g., acyclovir, zidovudine); phosphonate acid moieties; nucleoside monophosphate mimics (nucleotides). Anti‑inflammatory / Immunomodulatory Non‑steroidal anti‑inflam. core: aniline with carboxylic acid (aspirin), phenylacetic acid derivatives; steroid backbone (progesterone, hydrocortisone). Cancer Chemotherapeutics Aromatic amine/amine groups; anthracycline core with multiple aromatic rings and hydroxyl substituents; alkylating agents (chloroacetamide). Antiviral / Antimicrobial Macrolide lactone ring + sugar side‑chains; β‑lactam core; nucleoside analogs. --- 4. How to Use This Table Identify the scaffold in your unknown compound (e.g., benzamide, steroid nucleus, macrolide). Locate its characteristic functional groups using the "Key Functional Groups" column. Count the number of each group – this is a quick way to check whether the compound belongs to one of the classes listed. Check for unique motifs (e.g., β‑lactam carbonyl, oxazole ring) that only appear in specific drug families. Apply chemical intuition: - If the molecule has a steroid core → likely an anti‑inflammatory or hormone analog. - A macrolide with a lactone and deoxy sugar → probable macrolide antibiotic. - An oxazole‑containing thiazolidinedione → metabolic regulator. --- 5. Practical Example (Hypothetical) Suppose the unknown compound contains: One β‑lactam ring (four‑membered amide). Two amide carbonyls. No aromatic rings. Using the above approach, we would immediately suspect a penicillin‑type antibiotic because only those molecules in our knowledge base contain a β‑lactam ring without aromatics. 6. Conclusion By combining structural recognition with a concise reference list of drug families and their key motifs, you can rapidly deduce the likely pharmacological class of an unknown compound from its SMILES string alone. This method leverages pattern matching rather than exhaustive computational analysis, making it ideal for quick identification in a time‑constrained setting. Feel free to refer back to this guide whenever you need to identify drug families from SMILES strings quickly and accurately.
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[28071] This man wants you
投稿者：RobertPal 投稿日：2025/09/26(Fri) 06:21
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- Dr. Jake Scott is on the front line of his second pandemic in five years and he is not getting much sleep.
Scott works full-time as an infectious disease physician at Stanford Health Care’s Tri-Valley hospital in Pleasanton, California. When he is done taking care of his patients and his two grade-school aged kids, he often stays up past midnight writing furiously penning op-eds, collecting studies, leading evidence reviews and posting meaty threads on social media, most of them correcting the record on vaccines.
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Often, he’s reacting to the latest maneuvers by US Health and Human Services Secretary Robert F. Kennedy Jr.. A pinned post responding to one of Kennedy’s appearances on Fox News has been viewed almost 5 million times. Another post fact-checking Kennedy’s claims about potential harms from aluminum in vaccines had 1 million views in its first 48 hours. Scott’s followers on X have doubled since April.
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“A million views for this long-winded, very detailed, kind of nerdy breakdown of the science,” Scott said, marveling at the attention it got. “I think that’s saying something, you know? People want that information, and they deserve it,” said Scott who is 48.
The Covid-19 pandemic turned many infectious disease specialists and virologists into household names. Scott’s was not one of them, perhaps because he was too busy treating patients. He didn’t stay out of the public discourse completely, however. He was one of the first doctors to tell people that Omicron didn’t seem to be as severe an infection as earlier strains of the virus, although some virologists were skeptical at the time.
In President Donald Trump’s second administration, however, Scott is taking on what he sees as a second pandemic misinformation and disinformation about vaccines. He knows false information can be as harmful as any virus.
“When officials spread inaccurate information about vaccines, it does have real consequences, and families make decisions based on fear rather than on facts,” Scott said.
It’s already happening. The US Centers for Disease Control and Prevention recently reported data showing kindergarten vaccination rates continue to decline, as states make it easier to opt out of school vaccination requirements. Vaccine preventable diseases like measles and whooping cough are rising again, too.
Scott knows it could get much worse.
“In 2021, nearly every single patient I lost to Covid was unvaccinated by choice, and every colleague of mine has said the same thing.”https://tripscan43.biz